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Anti-TBP antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5700154
包装型号
规格纯度
价格
4713.83 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-TBP antibody produced in rabbit
HDL4
SCA17
GTF2D
TBP
TFIID
GTF2D1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.

免疫原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TBP (NP_001165556.1).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 35
37
species reactivity human
浓度 0.66 mg/ml
technique(s) western blot: 1:500-1:2000
UniProt登记号 P20226
运输 wet ice
储存温度 ?20℃
Gene Information human ... TBP(6908)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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