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位置: 首页> 品牌> Sigma-Aldrich> Anti-RPS6KB1 (Ab-424) antibody produced in rabbit

Anti-RPS6KB1 (Ab-424) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300527
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-RPS6KB1 (Ab-424) antibody produced in rabbit
Anti-S6K1 antibody produced in rabbit
Anti-S6K antibody produced in rabbit
Anti-PS6K antibody produced in rabbit
Anti-STK14A antibody produced in rabbit
Anti-ribosomal protein S6 kinase, 70kDa, polypeptide 1 antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

免疫原

Peptide sequence around aa. 422-426 (P-V-S-P-V), according to the protein RPS6KB1.

特点和优势

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目标描述

RPS6KB1 phosphorylates the Ribosomal Protein-S6. Activation of RPS6KB1 requires a complex, ordered series of conformational changes and phosphorylation reactions. While the role of sequential, multi-site phosphorylation has been extensively detailed, characterization of the priming step required to initiate this cascade has remained elusive. Probably this priming process is dependent on calcium. Calcium-dependent regulation of RPS6KB1 does not specifically target Thr-229 and Thr-389, the key regulatory phosphorylation sites; rather, calcium chelation results in a global inhibition of RPS6KB1 phosphorylation. The initial calcium-dependent process is required to release an inhibitory interaction between the C- and N-termini of RPS6KB1, thus allowing phosphorylation of key domains. The priming event involves formation of a calcium-dependent protein complex that releases the interaction between the N- and C-termini. RPS6KB1 is then accessible for activation by the kinases that target the known regulatory phosphorylation sites .

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 ~70 kDa
~85 kDa
species reactivity human, mouse, rat
浓度 1 mg/mL
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同位素/亚型 IgG
免疫原序列 (P-V-S-P-V)
NCBI登记号 NP_003152.1
UniProt登记号 P23443
运输 wet ice
储存温度 ?20℃
Gene Information human ... RPS6KB1(6198)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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