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位置: 首页> 品牌> Sigma-Aldrich> Anti-RB1 (Ab-795) antibody produced in rabbit

Anti-RB1 (Ab-795) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300385
规格纯度
affinity isolated antibody
价格
4618.16 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-RB1 (Ab-795) antibody produced in rabbit
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半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The gene encoding Retinoblastoma-associated protein (RB1) is a tumor suppressor gene localized on human chromosome 13q14.2.

免疫原

Peptide sequence around aa. 793-797 (P-S-S-P-L), according to the protein RB1.

生化/生理作用

Retinoblastoma-associated protein (RB1) modulates the cell cycle. It acts as a repressor of transcription mediated by E2 factor (E2F) and influences transcriptional silencing. RB1 modulates mitochondrial activities and has a role in the organisation of heterochromatin. Mutations in the gene encoding this protein have been associated with childhood retinoblastoma.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD00282455
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 ~110 kDa
species reactivity human
浓度 1 mg/mL
technique(s) western blot: 1:500-1:1000
同位素/亚型 IgG
免疫原序列 (P-S-S-P-L)
NCBI登记号 NP_000312.2
UniProt登记号 P06400
运输 wet ice
储存温度 ?20℃
Gene Information human ... RB1(5925)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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