Anti-Phospholipase A2 (CPLA2) antibody produced in rabbit

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一般描述

Cytosolic phospholipase A2, group IVa, (cPLA2, also known as cPLA2a, PLA2G4A) is a member of the PLA2 superfamily that catalyses the cleavage of fatty acids from thesn-2 position of phospholipids. PLA2 isoenzymes vary in their cellular localizations, Ca²⁺sensitivities and substrate specificities. cPLA2 mRNA is widely expressed in tissues and in various cell types including platelets, macrophages and endothelial cells.

应用

Anti-Phospholipase A2 (CPLA2) antibody produced in rabbit has been used in immunoblotting.

生化/生理作用

Cytosolic phospholipase A2 (cPLA2) catalyse the synthesis of precursors of proinflammatory mediators, such as prostaglandins and leukotrienes, through the release of arachidonic acid (AA) from membrane phospholipids. PLA2s play crucial roles in several cellular processes, including intracellular membrane trafficking, differentiation, proliferation and apoptosis. They are thought to play a role in oxidative and inflammatory responses in cerebral ischemia, Alzheimer′s disease (AD) and neuronal injury. Upon cell stimulation, cPLA2 is activated by increased intracellular Ca²⁺levels and phosphorylation, resulting in its translocation from the cytosol to the endoplasmic reticulum and the nuclear membrane. cPLA2 is phosphorylated and activated by either ERK1/2, p38 MAPK or JNK at three sites, Ser⁵⁰⁵, Ser⁵¹⁵and Ser⁷²⁷, depending on the cell type and agonist.

联系

synthetic peptide corresponding to amino acids 242-258 of human cPLA2 conjugated to KLH. The corresponding sequence is identical in mouse and rat cPLA2

外形

solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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