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位置: 首页> 品牌> Sigma-Aldrich> Anti-phospho-MKP-1/2 (pSer296/318) antibody produced in rabbit

Anti-phospho-MKP-1/2 (pSer296/318) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4504713
规格纯度
affinity isolated antibody
价格
4618.16 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-phospho-MKP-1/2 (pSer 296/318) antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

MKP1 (mitogen-activated protein kinase phosphatase 1)/DUSP1 (dual specificity phosphatase 1) is a dual specificity phosphatase. DUSP1 is also called as CL100, 3CH134 and Erp. MKP1 is located in the nucleus and is expressed in several tissues. The MKP gene is located on human chromosome 5q35.

免疫原

The antiserum was produced against synthesized peptide derived from human MKP-1/2 around the phosphorylation site of Ser296/318.

Immunogen Range:261-310

生化/生理作用

In mast cells, MKP1 (mitogen-activated protein kinase phosphatase 1) blocks the functions of extracellular signal-regulated kinase (Erk)‐1/2 by glucocorticoid. It controls axon branching promoted by BDNF (brain-derived neurotrophic factor). These results suggest that that DUSP4 is a critical regulator of the growth and invasion of triple-negative breast cancer cells. DUSP4 specifically regulates extracellular regulated kinase (ERK). DUSP4 is an important tumor suppressor gene in these aggressive breast cancers.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 39 kDa
species reactivity mouse, rat, human
浓度 ~1 mg/mL
technique(s) ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号 P28562
Q13115
UniProt登记号 P28562
运输 wet ice
储存温度 ?20℃
Gene Information human ... DUSP1(1843), DUSP4(1846)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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