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位置: 首页> 品牌> Sigma-Aldrich> Anti-phospho-IGF-1R (pTyr1280) antibody produced in rabbit

Anti-phospho-IGF-1R (pTyr1280) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300652
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-phospho-IGF-1R (pTyr 1280) antibody produced in rabbit
Anti-IGFIR
Anti-CD221
Anti-IGFR
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The antibody detects endogenous levels of IGF-1R only when phosphorylated at tyrosine 1280.

免疫原

Peptide sequence around phosphorylation site of tyrosine 1280 (S-F-Yp-Y-S), according to the protein NP_000866.1

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 200-295 kDa
species reactivity human
浓度 1 mg/mL
technique(s) western blot: 1:500-1:1000
同位素/亚型 IgG
免疫原序列 (S-F-Yp-Y-S)
NCBI登记号 NM_000875.3
运输 wet ice
储存温度 ?20℃
Gene Information human ... IGF-1R(3480)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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