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位置: 首页> 品牌> Sigma-Aldrich> Anti-MYL3, clone 7C1 Antibody

Anti-MYL3, clone 7C1 Antibody

品牌
Sigma-Aldrich
货号
MABT495
规格纯度
ascites fluid, clone 7C1, from mouse
价格
5520.38 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-MYL3, clone 7C1 Antibody
Myosin light chain 3, Cardiac myosin light chain 1, CMLC1, Myosin light chain 1, slow-twitch muscle B/ventricular isoform, MLC1SB, Ventricular/slow twitch myosin alkali light chain
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Myosin light chain 3 (MYL3), also known as Cardiac myosin light chain 1 (CMLC1) or Myosin light chain 1 slow-twitch muscle B/ventricular isoform (MLC1SB) or Ventricular/slow twitch myosin alkali light chain (VLC1) functions as a regulatory light chain of myosin. Myosins are a large superfamily of motor proteins that move along actin filaments, while hydrolyzing ATP. Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains and four light chains. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Human myosin light chain has clinical application as a cardiac marker. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.

免疫原

Purified recombinant fragment of human MYL3 expressed in E. Coli

应用

Research Category
Cell Structure
Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected MYL3 in human skeletal muscle and cardiac muscle tissues.
Detect MYL3 using this Anti-MYL3, clone 7C1 Antibody validated for use in western blotting & IHC.
Research Sub Category
Cytoskeleton

质量

Evaluated by Western Blotting in rat fetal heart tissue lysate.

Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected MYL3 in rat fetal heart tissue lysate.

目标描述

~25 kDa observed. Uncharacterized bands may be observed in some lysate(s).

外形

Unpurified
Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 ascites fluid
antibody product type primary antibodies
克隆 7C1, monoclonal
species reactivity rat
technique(s) immunohistochemistry: suitable
western blot: suitable
同位素/亚型 IgG1
UniProt登记号 P08590
运输 wet ice

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1

Sigma-Aldrich

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