半岛bd体育手机客户端 说明
一般描述
Anti-MDM2 antibody detects endogenous levels of total MDM2 protein.
Murine double minute 2 (MDM2) is an oncogenic protein. It is an E3 ubiquitin-protein ligase, that is mapped to human chromosome 12q15.
免疫原
The antiserum was produced against synthesized peptide derived from human MDM2.
Immunogen Range:132-181
应用
Anti-MDM2 antibody has been used in immunohistochemistry.
生化/生理作用
Murine double minute 2 (MDM2) is a negative regulator of the p53 tumor suppressor. It regulates cell cycle, cellular differentiation, cell fate determination, DNA repair and transcription. Epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells are induced by MDM2.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD00282354 |
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 55 kDa |
| species reactivity | human, mouse |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:1000 immunofluorescence: 1:100-1:500 western blot: 1:500-1:1000 |
| NCBI登记号 | Q00987 |
| UniProt登记号 | Q00987 |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... MDM2(4193) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
