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Anti-ID2 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300701
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-ID2 antibody produced in rabbit
Anti-ID2H
Anti-GIG8
Anti-ID2A
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The antibody detects endogenous level of total Id2 protein.
Id2 (inhibitor of DNA binding 2) belongs to the HLH (helix–loop–helix) family. It is located on human chromosome 2p25.

免疫原

Peptide sequence around aa. 5-9 (S-P-V-R-S), according to the protein NP_002157.2

生化/生理作用

Id2 (inhibitor of DNA binding 2) knockdown decreases the upregulation of N-cadherin, vimentin and Snail and promotes the expression of E-cadherin. It has the ability to interact with Rb protein and block its antiproliferative activity. It can prevent the separation of cells, stimulate multiplication of cell and help in reprogramming of Hodgkin lymphoma cells, the oncogenic AP-1 transcription factor FRA2 (fos-related antigen 2) and the oncogenic tyrosine kinase CSF-1 receptor.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 ~15 kDa
species reactivity rat, human, mouse
浓度 1 mg/mL
technique(s) western blot: 1:500-1:1000
同位素/亚型 IgG
免疫原序列 (S-P-V-R-S)
NCBI登记号 NM_002166.4
UniProt登记号 Q02363
运输 wet ice
储存温度 ?20℃
Gene Information human ... Id2(3398)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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