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位置: 首页> 品牌> Sigma-Aldrich> Anti-EIF2AK2 (Ab-451) antibody produced in rabbit

Anti-EIF2AK2 (Ab-451) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300533
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-EIF2AK2 (Ab-451) antibody produced in rabbit
Anti-PKR antibody produced in rabbit
Anti-MGC126524 antibody produced in rabbit
Anti-PRKR antibody produced in rabbit
Anti-eukaryotic translation initiation factor 2-alpha kinase 2 antibody produced in rabbit
Anti-EIF2AK1 antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

EIF2AK2 (eukaryotic translation initiation factor 2α kinase 2) is an intracellular protein, that is also called as RNA-dependent protein kinase (PKR). It belongs to the eIF2α family of protein kinases. It contains two RNA binding domains and a kinase domain. It is located on chromosome 2p22-p21.

免疫原

Peptide sequence around aa. 449-453 (K-G-T-L-R), according to the protein EIF2AK2.

生化/生理作用

EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) plays a key role in antiviral response promoted by interferon. It is involved in stress response and inflammation pathways. It controls the development and multiplication of cell, nutrient signaling and metabolism. It also participates in several cell regulatory pathways like antiviral activity, growth suppression, transcriptional regulation and apoptosis.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD03455796
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 ~74 kDa
species reactivity human
浓度 1 mg/mL
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
同位素/亚型 IgG
免疫原序列 (K-G-T-L-R)
NCBI登记号 NP_001129123.1
UniProt登记号 P19525
运输 wet ice
储存温度 ?20℃
Gene Information human ... EIF2AK2(5610)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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