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一般描述

CREB1 (cAMP response element-binding protein) gene codes for a 43kDa cellular transcription factor, CREB. It has 341 amino acids. It belongs to the basic leucine zipper family of transcription factors. It is upregulated abundantly in human tissues and is located on chromosome 2q33–35.

免疫原

Peptide sequence around aa. 131-135 (R-P-S-Y-R), according to the protein CREB1.

生化/生理作用

Knockdown of CREB (cAMP response element-binding protein) blocks the development and promotes apoptosis in pre-B acute lymphoblastic leukemia cells by preventing prosurvival signals. It controls the transcription of antiapoptotic proteins in several cell types. Decrease in CREB phosphorylation leads to malfunction of mitochondria and hypoxia-induced apoptosis in chondrocytes.

特点和优势

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目标描述

This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

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基本信息

半岛bd体育手机客户端 性质

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