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位置: 首页> 品牌> Sigma-Aldrich> Anti-CDK4 antibody produced in rabbit

Anti-CDK4 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300695
规格纯度
affinity isolated antibody
价格
4618.16 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-CDK4 antibody produced in rabbit
Anti-PSK-J3
Anti-CMM3
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The antibody detects endogenous levels of total CDK4 protein.

免疫原

Peptide sequence around aa. 295-299 (L-H-K-D-E), according to the protein NP_000066.1

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Cyclin-dependent kinase activity is regulated by T-loop phosphorylation (Thr172 in the case of CDK4), by the abundance of their cyclin partners, and by association with CDK inhibitors of the Cip/Kip or INK family of proteins . The inactive ternary complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27, which affects progression through the restriction point and pRb-dependent entry into S-phase . The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression . In HeLa cells, upon UV irradiation, upregulation of p16 INK4A association with CDK4/cyclin D3 leads to a G2 delay, implicating CDK4/cyclin D3 activity in progression through the G2-phase of the cell cycle .

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 ~34 kDa
species reactivity human
浓度 1 mg/mL
technique(s) western blot: 1:500-1:1000
同位素/亚型 IgG
免疫原序列 (L-H-K-D-E)
NCBI登记号 NM_000075.2
UniProt登记号 P11802
运输 wet ice
储存温度 ?20℃
Gene Information human ... CDK4(1019)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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