Anti-CCL2 antibody produced in rabbit

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一般描述

C-C motif chemokine ligand 2 (CCL2) gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. (provided by RefSeq).CCL2 is a pro-inflammatory cytokine. It belongs to the family of CC-type chemokines, which can be produced by almost every cells.

免疫原

CCL2 (NP_002973.1, 1 a.a. ~ 99 a.a) full-length human protein.

Sequence
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT

生化/生理作用

C-C motif chemokine ligand 2 (CCL2) plays a critical role in the development of allergic inflammatory reactions by employing immune cells, that is linked to autoimmune diseases. It binds to CC chemokine receptor 2 (CCR2) and regulates monocyte chemotaxis and T-lymphocyte differentiation. The protein recruits monocytes to liver. It is involved in macrophage fusion and foreign body giant cell formation.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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