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位置: 首页> 品牌> Sigma-Aldrich> Anti-c-Ret Antibody, clone 6F3.1

Anti-c-Ret Antibody, clone 6F3.1

品牌
Sigma-Aldrich
货号
MABC572
规格纯度
clone 6F3.1, from mouse
价格
6694.05 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-c-Ret Antibody, clone 6F3.1
Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1; UniProt P07949; also known as Cadherin family member 12, Cadherin-related family member 16, Hydroxyaryl-protein kinase, Proto-oncogene c-Ret, Rearranged during transfection, Receptor tyrosine kinase, Ret proto-oncogene, RET receptor tyrosine kinase, RET transforming sequence) is encoded by the RET (also known as CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51) gene (Gene ID 5979) in human. Ret is a receptor tyrosine kinase that mediates the activation of several signaling pathways including the PLC gamma, Ras, JNK and inositol phosphate pathways. Ret mutations have been shown to be causative in several diseases, including Hirschsprung′s disease (HD), papillary thyroid carcinoma, multiple endocrine neoplasia (MEN) 2A, MEN 2B, and familial medullary thyroid carcinoma. Ret is initially produced with a signal peptide sequence (a.a. 1-28), the removal of which yields the mature Ret (a.a. 20-1114). Ret can be posttranslationally cleaved into the extracellular cell-membrane-anchored RET cadherin 120 kDa fragment (a.a. 29-707) and the soluble RET kinase fragment (a.a. 708-1017).

特异性

Expected to react with both the RET51 and the RET9 isoforms, as well as the extracellular cell-membrane anchored RET cadherin 120 kDa fragment (a.a. 29-707).

免疫原

Epitope: Extracellular domain
GST-tagged recombinant protein corresponding to the extracellular domain of human c-Ret.

应用

Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
This Anti-c-Ret Antibody, clone 6F3.1 is validated for use in Western Blotting for the detection of c-Ret.

质量

Evaluated by Western Blotting in PC12 cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected c-Ret in 10 ?g of PC12 cell lysate.

目标描述

~150 kDa observed. 124.3 kDa (RET51) and 119.8 kDa (RET9) calculated. Target band(s) may appear larger than the calculated molecular size(s) due to posttranslational glycosylation and/or phosphorylation. Uncharacterized band(s) may appear in some lysates.

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 6F3.1, monoclonal
species reactivity rat
species reactivity (predicted by homology) human (based on 100% sequence homology)
technique(s) western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_066124
UniProt登记号 P07949
运输 wet ice
Gene Information human ... RET(5979)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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