Anti-Bcl-2 (ab1) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

B-cell lymphoma 2 (BCL2), a proto-oncogene is made of three exons. It is widely expressed in immature B-cells and memory B cells. BCL2 is found at high levels in the thymus, spleen, and lymph nodes. BCL2 gene is mapped to human chromosome 18q21.33.

免疫原

a peptide corresponding to 15 amino acids near the N-terminus of human Bcl-2.

应用

Anti-Bcl-2 (ab1) antibody produced in rabbit has been used in western blotting (1:100) (1:1000), immunohistochemistry (1:50), immunoprecipitation (IP) (1:1000)

生化/生理作用

B-cell lymphoma 2 (BCL2) plays a key role in maintaining the integrity of the mitochondrial membrane. It blocks the release of cytochrome C and its binding to apoptosis activating factor-1 (APAF1). BCL2 family proteins participate in modulating cell death. It also regulates apoptosis, necrosis, and autophagy. Upregulation of BCL2 is seen in several human cancers. Overexpression of BCL2 is observed in chronic lymphocytic leukemia (CLL), marginal cell lymphoma, and mantle cell lymphoma.

联系

The action of this antibody can be blocked using blocking peptide SBP3335.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD00239644
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
species reactivity	mouse, human
technique(s)	immunofluorescence: suitable immunohistochemistry: suitable indirect ELISA: suitable western blot: suitable
UniProt登记号	P10415
运输	dry ice
储存温度	?20℃
Gene Information	human ... BCL2(596)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable