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位置: 首页> 品牌> Sigma-Aldrich> Anti-BAD (Ab-136) antibody produced in rabbit

Anti-BAD (Ab-136) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300342
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-BAD (Ab-136) antibody produced in rabbit
Anti-BCL2L8 antibody produced in rabbit
Anti-BBC2 antibody produced in rabbit
Anti-BCL2-associated agonist of cell death antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

BAD (BCL2 associated agonist of cell death) is a proapoptotic protein. It is a 184 kDa protein made of 168 amino acids. It belongs to the Bcl2 family of proteins. The gene encoding it is localized on human chromosome 11q13.

免疫原

Peptide sequence around aa. 134-138 (S-R-S-A-P), according to the protein BAD.

生化/生理作用

Phosphorylated BAD (BCL2 associated agonist of cell death) has the ability to interact with 14-3-3 scaffold proteins in the cytoplasm. Dephosphorylated BAD is active and it moves to the outer membrane of mitochondria and make heterodimers with BCL-XL to prevent BCL-XL antiapoptotic activities.

特点和优势

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目标描述

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

基本信息

MDL编号 MFCD02097156
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 ~23 kDa
species reactivity rat, human, mouse
浓度 1 mg/mL
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
同位素/亚型 IgG
免疫原序列 (S-R-S-A-P)
NCBI登记号 NP_004313.1
UniProt登记号 Q92934
运输 wet ice
储存温度 ?20℃
Gene Information human ... BAD(572)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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