Anti-APC Antibody, clone CC-1

半岛bd体育手机客户端 说明

一般描述

Adenomatous polyposis coli protein (APC) is a ubiquitous multidomain protein that has a well documented role as a tumor suppressor. The mechanism of APC-mediated tumor suppression is still an area of active investigation; however, several studies suggest that APC is a negative regulator of the Wnt signaling pathway as it downregulates β-catenin via interactions with Axin/GSK3-β complex, thereby preventing transcription of genes such as MYC that contribute to cell proliferation. Defective APC proteins contribute to the initiation and proliferation of various types of cancers, including familial adenomatous polyposis. However, other studies have shown that APC interacts with a range of other proteins such as the EB1 microtubule-binding proteins, to regulate other processes such as cell migration.

免疫原

Recombinant protein corresponding to human APC.

应用

Anti-APC Antibody, clone CC-1 detects levels of APC proteins & has been published & validated for use in IHC.
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in human brain tissue containing multiple schlerosis lesions (Saikali, P. et al. (2007). J Neurosci. 27(5):1220-1228.).

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in rat spinal cord injury tissue (McTique, D. M., et al. (2001). J Neurosci. 21(10):3392-3400.).

质量

Immunohistochemistry Analysis: A 1:5 dilution from a representative lot detected APC in human colorectal cancer tissue, human smooth muscle tissue, and human colon tissue.

目标描述

311 kDa calculated

外形

Protein G Purified
Format: Purified

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	CC-1, monoclonal
species reactivity	human
technique(s)	immunohistochemistry: suitable
同位素/亚型	IgG2bκ
NCBI登记号	NP_000029
UniProt登记号	P25054
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable