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位置: 首页> 品牌> Sigma-Aldrich> Anti-Androgen Receptor antibody produced in rabbit

Anti-Androgen Receptor antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5700763
包装型号
规格纯度
价格
4713.83 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Androgen Receptor antibody produced in rabbit
AIS
TFM
AR8
KD
HUMARA
NR3C4
DHTR
HYSP1
AR
SBMA
SMAX1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

免疫原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Androgen Receptor (NP_000035.2).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 44
67
99
species reactivity human, mouse
浓度 5.58 mg/ml
technique(s) immunohistochemistry: 1:50-1:100
western blot: 1:500-1:2000
UniProt登记号 P10275
运输 wet ice
储存温度 ?20℃
Gene Information human ... AR(367)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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