Anti-RAB8A Antibody

半岛bd体育手机客户端 说明

一般描述

Ras-related protein Rab-8A (RAB8A) is one of two Rab8 isoforms, which belong to the superfamily of GTPases. They cycle between an active GTP-bound state, formed from interaction with guanine nucleotide exchange factors (GEFs) such as Rabin8 and GRAB; and an inactive GDP-bound state via interaction with GTPase activating proteins (GAPs) such as TBC1D1. Rab8A activates various effector molecules, which are coupled to intracellular signaling networks that mediate membrane and vesicular trafficking, and actin remodeling. Rab8A is found in the golgi network, perinuclear region, plasma membrane, lamellipodia, and cilia, among other regions.

特异性

This antibody recognizes the C-terminus of RAB8A.

免疫原

KLH-conjugated linear peptide corresponding to the C-terminus of human RAB8A.
Epitope: C-terminus

应用

Research Category
Cell Structure
Western Blot Analysis: A representative lot from an independent laboratory detected RAB8A in human cerebellum and brain.
Research Sub Category
Vesicular Trafficking
This Anti-RAB8A Antibody is validated for use in Western Blotting for the detection of RAB8A.

质量

Evaluated by Western Blot in serum starved HeLa cell lysate.

Western Blot Analysis: 1 ?g/mL of this antibody detected RAB8A in serum starved HeLa cell lysate.

目标描述

~24 kDa observed. Uncharacterized bands may be observed at ~110 kDa and ~38 kDa

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Serum starved HeLa cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	human
species reactivity (predicted by homology)	mouse (based on 100% sequence homology), bovine (based on 100% sequence homology)
technique(s)	western blot: suitable
NCBI登记号	NP_005361
UniProt登记号	P61006
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable