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位置: 首页> 品牌> Sigma-Aldrich> 1,3-二氮杂-2,4-环戊二烯

Imidazole

咪唑

品牌
Sigma-Aldrich
CAS
288-32-4
货号
RDD039
规格纯度
for molecular biology, ≥99% (titration), free-flowing, Redi-DriTM
价格
9048.1 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
288-32-4
Imidazole
1,3-Diaza-2,4-cyclopentadiene
Glyoxaline
咪唑
甘恶啉
1,3-二氮杂-2,4-环戊二烯
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.

应用

Imidazole has been used

  • in the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein
  • in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography
  • as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells


特别适用于 pH 6.2-7.8 范围内的缓冲液

生化/生理作用

Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).

法律信息

Redi-Dri is a trademark of sigma-aldrich Co. LLC

基本信息

经验(实验)分子式 C3H4N2
分子量 68.08
Beilstein 103853
MDL编号 MFCD00005183

半岛bd体育手机客户端 性质

质量水平 100
等级 for molecular biology
蒸汽压 <1 mmHg ( 20 ℃)
半岛bd体育手机客户端 线 Redi-Dri?
测定 ≥99% (titration)
形式 crystalline powder
质量 free-flowing
pH值(酸碱度) 6.2-7.8 (25 ℃)
pKa (25 ℃) 6.95
bp 256 ℃ (lit.)
mp 88-91 ℃ (lit.)
application(s) diagnostic assay manufacturing
异质活性 DNase, RNase and protease, none detected
SMILES string c1c[nH]cn1
InChI 1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
InChI key RAXXELZNTBOGNW-UHFFFAOYSA-N

安全信息

象形图 GHS05GHS07GHS08
警示用语: Danger
危险声明 H302 - H314 - H360D
预防措施声明 P201 - P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338 + P310 - P308 + P313
危险分类 Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
储存分类代码 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK WGK 2
闪点(F) 293.0 °F - closed cup
闪点(C) 145 ℃ - closed cup

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