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IL-3 from mouse

IL-3 来源于小鼠

品牌
Sigma-Aldrich
货号
SRP3208
规格纯度
Animal-component free, recombinant, expressed inE. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
价格
5283.88 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
IL-3 from mouse
HCGF
Multi-CSF
P-cell stimulation factor
MCGF (Mast cell growth factor)
IL-3 来源于小鼠
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

IL-3 (interleukin 3) is primarily produced by activated CD4+T cells and mast cells, and is a multi-lineage hematopoietic growth factor and immunoregulatory cytokine.
Recombinant murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.

生化/生理作用

IL-3 (interleukin 3) plays a key role in the differentiation of murine hematopoietic progenitor cells and the activation and survival of mature myeloid cells. This protein was originally termed as multicolony-stimulating factor (multi-CSF) because of its capability to induce the differentiation of a wide variety of hematopoietic progenitor cells from bone marrow, such as mast cells, basophils, neutrophils, eosinophils, macrophages, dendritic cells, erythrocytes, and megakaryocytes. IL-3 promotes mast cell growth, differentiation, and mediator release, hence, suggesting a role in allergic inflammation. In mice, it is involved in suppressing protective immunity againstPlasmodium bergheiNK651, and prevents the development of splenomegaly, anemia, and erythropoiesis. It functions as a regulator of osteoclastogenesis, where it play a dual role- it facilitate the development of osteoclast progenitors but suppresses the osteoclastogenic process.

序列

MDTHRLTRTL NCSSIVKEII GKLPEPELKT DDEGPSLRNK SFRRVNLSKF VESQGEVDPE DRYVIKSNLQ KLNCCLPTSA NDSALPGVFI RDLDDFRKKL RFYMVHLNDL ETVLTSRPPQ PASGSVSPNR GTVEC

外形

Lyophilized from 0.1% TFA.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 mouse
重组 expressed inE. coli
测定 ≥98% (HPLC)
≥98% (SDS-PAGE)
形式 lyophilized
效能 ≤0.05 ng/mL ED50
分子量 15.1 kDa
包装 pkg of 10 μg
technique(s) cell culture | mammalian: suitable
杂质 <0.1 EU/μg endotoxin, tested
颜色 white to off-white
UniProt登记号 P01586
运输 wet ice
储存温度 ?20℃
Gene Information mouse ... IL3(16187)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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