Sodium Butyrate

半岛bd体育手机客户端 说明

应用

Sodium Butyrate has been used:

• to inhibit histone deacetylase (HDAC) and study its effect on fibroblast growth factor 21 (FGF21) expression in liver
• to inhibit deacetylase activity in embryonic stem (ES) cells to determine if the enzymatic activity of the mSin3A-HDAC complex is essential for Nanog expression
• as a reagent during tissue homogenization
• as a supplement in chromatin immunoprecipitation (ChIP) dilution buffer

生化/生理作用

Sodium Butyrate is a short-chain fatty acid and a histone deacetylase inhibitor. It protects dopaminergic neuronal cells from α-synuclein mediated transcriptional deregulation and DNA damage, maybe by enhancing the expression of DNA-repair genes. Sodium butyrate may promote the production of foreign proteins such as erythropoietin, tissue plasminogen activator, antibody, and nitric oxide synthase in recombinant Chinese hamster ovary (rCHO) cell cultures. But, the higher concentration of sodium butyrate in rCHO cell cultures may also exhibit a cytotoxic effect on cell growth by inducing apoptosis. Sodium Butyrate prevents the growth of cancer cells by downregulating the thioredoxin 1 (Trx1) expression, stimulating reactive oxygen species (ROS) production, and inhibiting cell proliferation and migration of various carcinoma cells including colorectal cancer (CRC).

外形

CH₃CH₂CH₂COONa

储存及稳定性

1 year at 4°C

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160405
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
manufacturer/tradename	Upstate?
technique(s)	activity assay: suitable (histone deacetylase (HDAC))
运输	wet ice

安全信息

象形图
警示用语：	Danger
危险声明	H314
预防措施声明	P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
危险分类	Eye Dam. 1 - Skin Corr. 1B
储存分类代码	8B - Non-combustible, corrosive hazardous materials
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable