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位置: 首页> 品牌> Sigma-Aldrich> Anti-phospho-MKK7/SKK4 (Thr275/Ser277) Antibody

Anti-phospho-MKK7/SKK4 (Thr275/Ser277) Antibody

品牌
Sigma-Aldrich
货号
36-010
规格纯度
Upstate?, from rabbit
价格
5426.21 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-phospho-MKK7/SKK4 (Thr275/Ser277) Antibody
Dual specificity mitogen-activated protein kinase kinase 7, EC:2.7.12.2, MAP kinase kinase 7, MAPKK 7, JNK-activating kinase 2, MAPK/ERK kinase 7, MEK 7, Stress-activated protein kinase kinase 4, SKK4, SAPK kinase 4, SAPKK-4, SAPKK4, c-Jun N-terminal kin
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Dual specificity mitogen-activated protein kinase kinase 7 (UniProt: O14733; also known as EC:2.7.12.2, MAP kinase kinase 7, MAPKK 7, JNK-activating kinase 2, MAPK/ERK kinase 7, MEK 7;Stress-activated protein kinase kinase 4, SKK4, SAPK kinase 4, SAPKK-4, SAPKK4, c-Jun N-terminal kinase kinase 2,JNK kinase 2, JNKK 2) is encoded by the MAP2K7 (also known as JNKK2, MEK7, MKK7, RKMK7, SKK4) gene (Gene ID: 5609) in human. MKK4/SKK4 belongs to the STE Ser/Thr protein kinase family and is an essential component of the MAP kinase signal transduction pathway. MKK4/SKK4 is ubiquitously expressed with highest level of expression reported in skeletal muscle. It contains a single protein kinase domain and has a DVD domain (aa 377-400) that contains a conserved docking site and bind to their specific upstream MAP kinase kinase kinases (MAPK3Ks). MKK4/SKK4 also has a D domain in the N-terminal region (aa 37-57), which contains a conserved docking site that is required for the binding of MAPK substrates. It is activated by phosphorylation on Ser271 and Thr275 by MAP kinase kinase kinases (MAP3Ks) and it directly phosphorylates and activates the c-Jun NH2-terminal kinases (JNK), in response to cellular stresses and pro-inflammatory cytokines. Mice lacking the MKK4 gene are shown to have abnormal hepatogenesis and die before embryonic day 14.

特异性

This rabbit polyclonal antibody detects MKK7/SKK4 phosphorylated on Thr275/Ser277.

免疫原

peptide corresponding to amino acids surrounding Thr275/Ser277 of human MKK7/SKK4.

应用

Anti-Phospho-MKK7/SKK4 (Thr275/Ser277), Cat. No. 36-010, is a highly specific rabbit polyclonal antibody that detect dual specificity mitogen-activated protein kinase kinase 7 (MKK7) and has been tested for use in Western Blotting.

质量

Evaluated by Western Blotting in lysate of A431 cells treates with Calyculin A and okadaic acid.

Western Blotting Analysis: A 1:500 dilution of this antibody detected Phospho-MKK7/SKK4 (Thr275/Ser277) in lysate from 10 ?g of A431 cells treated with Calyculin A and okadaic acid.

目标描述

~47kDa

外形

ImmunoAffinity Purified

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
species reactivity (predicted by homology) rat (based on 100% sequence homology), mouse (based on 100% sequence homology)
manufacturer/tradename Upstate?
technique(s) western blot: suitable
同位素/亚型 IgG
NCBI登记号 NM_145185.2
UniProt登记号 O14733
运输 dry ice
Gene Information human ... MAP2K7(5609)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1

Sigma-Aldrich

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