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位置: 首页> 品牌> Sigma-Aldrich> Anti-Integrin β1 Antibody, clone P5D2 (Azide Free)| MAB1959

Anti-Integrin β1 Antibody, clone P5D2 (Azide Free)| MAB1959

品牌
Sigma-Aldrich
货号
MAB1959Z
规格纯度
clone P5D2, Chemicon?, from mouse
价格
5358.91 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-Integrin β1 Antibody, clone P5D2 (Azide Free)| MAB1959
CD29, MAB1959
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.

特异性

Reacts with Human Integrin Beta 1.

免疫原

Human keratinocytes derived from skin.

应用

Research Category
Cell Structure
Research Sub Category
Integrins
Immunoprecipitation:A representative lot of this antibody clone was used in immunoprecipitation.

Immunohistochemistry:A representative lot of this antibody clone was used in immunohistochemistry (acetone fixation, no paraffin embedding).

ELISA:A representative lot of this antibody was used in ELISA.

Immunocytochemistry:A representative lot of this antibody clone was used in immunocytochemistry (paraformaldehyde fixation at less than 4%).

Functional Activity Assay:A representative lot of this antibody clone was used in cell attachment assay of SV-HFO cells with a characteristic spread morphology. In the presence of function-blocking mAbs to β1 integrin (P5D2), the cells attached but no longer spread, and displayed a rounded morphology with many cytoplasmic projections (Iba, K. et al., 2000).
Anti-Integrin β1 Antibody, clone P5D2 (Azide Free) detects level of Integrin β1 & has been published & validated for use in ELISA, FC, IC, IH, IP, FUNC.

质量

Flow Cytometry Analysis:
4 ?g of the antibody was used to detect Integrin β1 in 1x10^6 A431 cells.
4 ?g of the antibody was used to detect Integrin β1 in 1x10^6 HeLa cells.

外形

Purified ascites in PBS without preservatives.
Format: Purified
Protein A purified

储存及稳定性

Store at -20°C in undiluted aliquots.
Avoid repeated freeze-thaw cycles.

分析说明

Control
Human tonsil, human skin tissue

A431 & HeLa Cells

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified antibody
antibody product type primary antibodies
克隆 P5D2, monoclonal
species reactivity human
manufacturer/tradename Chemicon?
technique(s) ELISA: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
同位素/亚型 IgG2bκ
NCBI登记号 NM_002211.2
NM_033666.1
NM_033667.1
NM_033668.1
NM_033669.1
NM_133376.1
UniProt登记号 P05556
运输 wet ice
Gene Information human ... ITGB1(3688)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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