半岛bd体育手机客户端 说明
一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
生化/生理作用
尼可地尔是一种杂合ATP敏感性K+(KATP)通道开放剂，也是烟酰胺硝酸盐NO供体。尼可地尔能够选择性激活含有SUR2B-和SUR2A-的KATP通道。它可以增强内皮NO合酶的表达，并防止缺血性室性心律失常。尼可地尔通过激活钾离子通道并提供一氧化氮激活鸟苷酸环化酶，引起GMP活化，从而导致动脉和静脉血管舒张。尼可地尔对血管钾离子通道具有选择性，但对心肌收缩和传导没有明显作用。
包装
Unit quantity: 5 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
基本信息
| 经验(实验)分子式 | C8H9N3O4 |
| 分子量 | 211.17 |
| MDL编号 | MFCD00186520 |
| PubChem化学物质编号 | 329831558 |
| NACRES | NA.24 |
半岛bd体育手机客户端 性质
| 等级 | pharmaceutical primary standard |
| manufacturer/tradename | EDQM |
| application(s) | pharmaceutical (small molecule) |
| 格式 | neat |
| 储存温度 | ?20℃ |
| SMILES string | [O-][N+](=O)OCCNC(=O)c1cccnc1 |
| InChI | 1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12) |
| InChI key | LBHIOVVIQHSOQN-UHFFFAOYSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H242 - H302 |
| 预防措施声明 | P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410 |
| 危险分类 | Acute Tox. 4 Oral - Org. Perox. D |
| 储存分类代码 | 5.2 - Organic peroxides and self-reacting hazardous materials |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
