Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor^?488

半岛bd体育手机客户端 说明

一般描述

The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells

特异性

Reacts with the low affinity nerve growth factor receptor (NGFR p75). The epitope recognized by the antibody maps within the third or fourth cysteine-rich repeats of the NGFR molecule. Reactivity has not been observed with rat, chicken, or mouse NGFR.

免疫原

Human melanoma cell line.

应用

This Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor 488 is validated for use in FC, IC for the detection of Nerve Growth Factor Receptor.

储存及稳定性

Aliquot and store at -20 ?C, or glycerol (ASC grade or better) can be added (1:1) and the antibody stored at -20?C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.

法律信息

ALEXA FLUOR is a registered trademark of Life Technologies
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Alexa Fluor^?is a registered trademark of Molecular Probes, Inc.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
偶联物	ALEXA FLUOR?488
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	ME20.4, monoclonal
species reactivity	human, sheep, pig, rabbit
should not react with	rat, chicken, mouse
manufacturer/tradename	Chemicon?
technique(s)	flow cytometry: suitable immunocytochemistry: suitable
同位素/亚型	IgG1
NCBI登记号	NM_002507.2
UniProt登记号	P08138
运输	dry ice
Gene Information	human ... NGFR(4804)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable