Anti-WAVE antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

The WASP family members include WASP, N-WASP and WAVE (WASP-family verprolin homologous protein) proteins. WAVE proteins (also termed SCAR, WASF proteins), include three isoforms WAVE-1, WAVE-2 and WAVE-3. Expression of WAVE-1 and WAVE-3 isoforms is restricted to the brain, while WAVE-2 is ubiquitously expressed. WAVE-1-3 have structures like WASP and N-WASP; these include two conserved domains: a WAVE homology domain (WHD), also known as SCAR homology domain (SHD), a C-terminal acidic domain that binds to the Arp2/3 complex; and a central core domain composed of proline-rich sequences that interact with cofilin and various SH3 proteins.

免疫原

synthetic peptide corresponding to amino acids 540-559 located at the C-terminus of human WAVE-1. The sequence is identical in several species, including mouse and rat WAVE-1 and is conserved (75% sequence identity) in other WAVE isoforms.

应用

Anti-WAVE antibody produced in rabbit has been used in immunoblotting.

生化/生理作用

WAVE proteins also play key roles in the induction of various actin remodelling processes including membrane ruffling and lamellipodia formation. WAVE proteins bind to phosphatidylinositol-3,4,5 triphosphate (PI-3,4,5P3) formed by PI3-kinase, thus facilitating WAVE translocation to the plasma membrane. WAVE proteins are thought to mediate Rac activity indirectly via the target protein IRSp53 or by binding to a macromolecular complex that includes PIR121, Nck-associated protein 1 (Nap1), Abi, and HSPC300 proteins.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD04118689
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen 75 kDa
species reactivity	human, rat, mouse
浓度	~1.5 mg/mL
technique(s)	microarray: suitable western blot: 0.2-0.4 μg/mL using rat and mouse brain cytosolic fraction (S1)
UniProt登记号	Q92558
运输	dry ice
储存温度	?20℃
Gene Information	human ... WASF1(8936) mouse ... Wasf1(83767) rat ... Wasf1(294568)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable