Anti-phospho-WAVE-1 (pSer³⁹⁷) antibody produced in rabbit

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一般描述

WAS protein family member 1 (WAVE-1) is encoded by the gene mapped to human chromosome 6q21. The encoded protein contains small WH2 acidic domain, a cofilin-like domain, proline-rich domain at C-terminal end and EVH1 domain at N-terminal end. WAVE-1 is active mainly in the brain and lungs, but its mRNA is also found in the placenta, liver and pancreas.

生化/生理作用

WAS protein family member 1 (WAVE-1) functions as a key pro-autophagic protein. The protein has an ability to increase cell survival rate. In addition, it also controls chemoresistance in leukemia cells via Beclin1/ B-cell lymphoma 2 (Bcl)-2 and Beclin1/ phosphatidylinositol 3-kinases (PI3K)-III complex-dependent pathways. The encoded protein enhances ovarian cancer cell proliferation, migration and invasion via activating PI3K/AKT (protein kinase B) and mitogen activated protein kinase p38 (p38MAPK) signaling pathways.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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