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Anti-VPS34 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
V9764
规格纯度
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
5693.71 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-VPS34 antibody produced in rabbit
Anti-Vacuolar protein sorting 34
Anti-Phosphoinositide-3-kinase
Vps34 Antibody-Anti-VPS34 antibody produced in rabbit
Vps34 Antibody
Anti-PIK3C3
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Vacuolar protein sorting 34 (VPS34), also known as phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3), is encoded by the gene mapped to human chromosome 18q12.3. The encoded protein belongs to the phosphoinositide (PI)-3-kinase family. VPS34 is widely expressed in all tissues of mammals.

免疫原

synthetic peptide corresponding to amino acids 22-34 of human VPS34, conjugated to KLH via an added cysteine residue. The corresponding sequence is identical in mouse and rat.

应用

Anti-VPS34 antibody produced in rabbit has been used in immunoblotting.

生化/生理作用

Vacuolar protein sorting 34 (VPS34) is a lipid kinase that phosphorylate phosphatidylinositol (PtdIns), to form phosphatidylinositol 3 phosphate (PtdIns3P). VPS34 plays a vital role in various intracellular trafficking events such as autophagy and phagosome formation. Thus, the inhibition of kinase activity of Vps34 might be considered as a potential therapeutic method for cancer treatment. VPS34 is also involved in internal vesicle formation within multivesicular endosomes, reverse transport of endosome to Golgi apparatus and membrane transport from the outer nuclear membrane towards the cell periphery. Mutation in the gene encoding VPS34 is associated with pathogenesis of schizophrenia. VPS34 plays an essential role in nutrient/amino acid induced activation of mechanistic target of rapamycin (mTOR) signaling in cultured cells and it also facilitates early embryogenesis and cell proliferation.

目标描述

VPS34 is known to be involved in endocytosis and vesiculartrafficking.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~105 kDa
species reactivity rat, mouse, human
浓度 ~1.0 mg/mL
technique(s) indirect immunofluorescence: suitable
western blot: 2-4 μg/mL using whole extracts of HEK-293T cells expressing human VPS34
UniProt登记号 Q8NEB9
运输 dry ice
储存温度 ?20℃
Gene Information human ... PIK3C3(5289)
mouse ... Pik3c3(225326)
rat ... Pik3c3(65052)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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