半岛bd体育手机客户端 说明
生化/生理作用
Infected cell protein 0 of herpes simplex virus 1 was shown to bind UbcH3 and induce its degradation by promoting its polyubiquination. This resulted in increased expression of an UbcH3-target gene cyclin D1 and aided in further viral infection.
Cdc34 is an essential gene for viability in yeast. Cdc34 mediates the transition from G1to S-phase of the cell cycle by degrading the S-phase cyclin/CDK inhibitor, SIC1 in yeast and p27(KIP1) in human. Cdc34 is also known to interact with the Skp1/Cdc53/F-box (SCF) ubiquitin ligase subunits Cul1 to degrade the NF-κB inhibitor IκBα in a phosphorylation-dependent manner.
外形
Solution in 50 mM HEPES, 200 mM NaCl, 1 mM TCEP (pH 7.5), and 10% glycerol.
其他说明
Manufactured for Sigma by Boston Biochem. Inc.
基本信息
MDL编号 | MFCD03101856 |
NACRES | NA.56 |
半岛bd体育手机客户端 性质
质量水平 | 200 |
生物来源 | human |
重组 | expressed inE. colioverproducing strain |
测定 | ≥95% (SDS-PAGE) |
形式 | solution |
分子量 | ~32 kDa |
UniProt登记号 | P49427 P61088 |
application(s) | cell analysis |
运输 | dry ice |
储存温度 | ?70℃ |
Gene Information | human ... CDC34(997), UBE2N(7334) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich