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Ubiquitin Carrier Protein H3/CDC34 human

品牌
Sigma-Aldrich
货号
U2383
规格纯度
≥95% (SDS-PAGE), recombinant, expressed inE. colioverproducing strain
价格
6313.46 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Ubiquitin Carrier Protein H3/CDC34 human
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Infected cell protein 0 of herpes simplex virus 1 was shown to bind UbcH3 and induce its degradation by promoting its polyubiquination. This resulted in increased expression of an UbcH3-target gene cyclin D1 and aided in further viral infection.
Cdc34 is an essential gene for viability in yeast. Cdc34 mediates the transition from G1to S-phase of the cell cycle by degrading the S-phase cyclin/CDK inhibitor, SIC1 in yeast and p27(KIP1) in human. Cdc34 is also known to interact with the Skp1/Cdc53/F-box (SCF) ubiquitin ligase subunits Cul1 to degrade the NF-κB inhibitor IκBα in a phosphorylation-dependent manner.

外形

Solution in 50 mM HEPES, 200 mM NaCl, 1 mM TCEP (pH 7.5), and 10% glycerol.

其他说明

Manufactured for Sigma by Boston Biochem. Inc.

基本信息

MDL编号 MFCD03101856
NACRES NA.56

半岛bd体育手机客户端 性质

质量水平 200
生物来源 human
重组 expressed inE. colioverproducing strain
测定 ≥95% (SDS-PAGE)
形式 solution
分子量 ~32 kDa
UniProt登记号 P49427
P61088
application(s) cell analysis
运输 dry ice
储存温度 ?70℃
Gene Information human ... CDC34(997), UBE2N(7334)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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