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Anti-Tal (CS-15) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
T1075
规格纯度
affinity isolated antibody, buffered aqueous solution
价格
4731.57 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-Tal (CS-15) antibody produced in rabbit
Anti-Tsg101-associated ligase
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Tsg101-associated ligase (TAL), contains an N-terminal leucine-rich repeat (LRR), followed by an ezrin-radixin-moesin (ERM) domain, a coiled-coil (CC) region, a sterile alpha motif (SAM) domain and a C-terminal C3HC4-type RING finger domain. Also called leucine-rich repeat and sterile alpha motif-containing protein 1 (LRSAM1), TAL is an E3 ubiquitin ligase. TAL gene is mapped to human chromosome 9.

特异性

Anti-Tal (CS-15) recognizes human, dog, rat, and mouse Tal (84 kDa, may appear as doublet).

免疫原

synthetic peptide encoding amino acids 709-723 located near the C-terminus of human Tal, conjugated to KLH. This sequence is highly conserved in mouse and rat Tal (two amino acids substitution).

应用

Anti-Tal (CS-15) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

生化/生理作用

Tsg101-associated ligase (TAL) plays a key role in cell signaling, cell adhesion and regulates cargo sorting. Reduced expression of Tsg101 shunts active epidermal growth factor receptor (EGFRs) from the normal degradative pathway to a recycling route. Tal, which interacts with Tsg101 associates with and ubiquitylates Tsg101 in a manner that regulates receptor trafficking and budding of viral particles. Tal binds to Tsg101 in a bimodal mode, through an interaction of its CC domain with the steadiness box (SB) of Tsg101, and also via binding of the UEV domain of Tsg101 with two PTAP motifs just upstream of the C-terminal RING domain. Tal interaction with Tsg101 promotes multiple monoubiquitination of Tsg101, rather than polyubiquitination, which leads to the release of Tsg101 from membrane complexes and its inactivation. Mutations in the TAL gene is implicated in Charcot-Marie-Tooth (CMT) syndrome.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

储存及稳定性

For continuous use, store at 2-8 ℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in frost-free freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses,in vitrodiagnostic uses,ex vivoorin vivotherapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD06798551
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 84 kDa
species reactivity canine, human, rat, mouse
technique(s) immunoprecipitation (IP): 5-10 μg using mouse brain S1 cytosolic fraction
microarray: suitable
western blot: 0.1-0.2 μg/mL using whole extract of human epitheloid carcinoma HeLa cell line and also canine kidney MDCK cell line
western blot: 0.2-0.4 μg/mL using whole extract of rat brain S1 cytosolic fraction
UniProt登记号 Q6UWE0
运输 dry ice
储存温度 ?20℃
Gene Information human ... LRSAM1(90678)
mouse ... Lrsam1(227738)

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