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Tocainide hydrochloride

Tocainide 盐酸盐

品牌
Sigma-Aldrich
CAS
71395-14-7
货号
T0202
规格纯度
≥98% (HPLC), solid
价格
1838.92 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
71395-14-7
Tocainide hydrochloride
2-Amino-N-(2,6-dimethylphenyl)propanamide hydrochloride
Tocainide 盐酸盐
2-Amino-N-(2,6-dimethylphenyl)propanamide 盐酸盐
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Tocainide hydrochloride may be used in cell signaling studies.

包装

10, 50 mg in glass bottle

生化/生理作用

Tocainide hydrochloride is a primary amine analog of lidocaine (lignocaine), used for the treatment of tinnitus. It blocks the sodium channels in the pain-producing foci in the nerve membranes and renders an analgesic effect in trigeminal neuralgia.
Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic.

特点和优势

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Tocainide is voltage-dependent and use-dependent sodium channel blocker (class IB type antiarrhythmic); Ki= 115 μM in blockade of inactivated-state sodium channels; IC50= 985μM in blockade of Na+ currents at a holding potential (HP) of -140 mV; IC50= 254 μM in blockade of Na+ currents at HP -70 mV; IC50= 523 μM in blockade of Na+ currents at tonic block (-100 mV); IC50= 248 μM for use-dependent block at 10 Hz.

基本信息

经验(实验)分子式 C11H16N2O · HCl
分子量 228.72
EC 号 275-361-2
MDL编号 MFCD00941502
PubChem化学物质编号 24724626
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
储存条件 desiccated
under inert gas
颜色 white
溶解性 DMSO: >20 mg/mL
H2O: ≥5 mg/mL
创始人 AstraZeneca
储存温度 2-8℃
SMILES string Cl[H].CC(N)C(=O)Nc1c(C)cccc1C
InChI 1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H
InChI key AMZACPWEJDQXGW-UHFFFAOYSA-N
Gene Information human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
危险分类 Acute Tox. 4 Oral
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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