半岛bd体育手机客户端 说明
应用
Tocainide hydrochloride may be used in cell signaling studies.
包装
10, 50 mg in glass bottle
生化/生理作用
Tocainide hydrochloride is a primary amine analog of lidocaine (lignocaine), used for the treatment of tinnitus. It blocks the sodium channels in the pain-producing foci in the nerve membranes and renders an analgesic effect in trigeminal neuralgia.
Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic.
特点和优势
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Tocainide is voltage-dependent and use-dependent sodium channel blocker (class IB type antiarrhythmic); Ki= 115 μM in blockade of inactivated-state sodium channels; IC50= 985μM in blockade of Na+ currents at a holding potential (HP) of -140 mV; IC50= 254 μM in blockade of Na+ currents at HP -70 mV; IC50= 523 μM in blockade of Na+ currents at tonic block (-100 mV); IC50= 248 μM for use-dependent block at 10 Hz.
基本信息
经验(实验)分子式 | C11H16N2O · HCl |
分子量 | 228.72 |
EC 号 | 275-361-2 |
MDL编号 | MFCD00941502 |
PubChem化学物质编号 | 24724626 |
NACRES | NA.77 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | solid |
储存条件 | desiccated under inert gas |
颜色 | white |
溶解性 | DMSO: >20 mg/mL H2O: ≥5 mg/mL |
创始人 | AstraZeneca |
储存温度 | 2-8℃ |
SMILES string | Cl[H].CC(N)C(=O)Nc1c(C)cccc1C |
InChI | 1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H |
InChI key | AMZACPWEJDQXGW-UHFFFAOYSA-N |
Gene Information | human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H302 |
危险分类 | Acute Tox. 4 Oral |
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich