α-Synuclein A53T human

半岛bd体育手机客户端 说明

一般描述

α-Synuclein is mapped to human chromosome 4q22.1. It is an intrinsically disordered protein with N-terminal imperfect repeats (KTKEGV), a central NAC crucial for aggregation and an acidic rich flexible C-terminal region.α-Synuclein is present in the Lewy bodies (LBs) and Lewy neurites (LNs).

应用

α-Synuclein A53T human has been used to treat mesencephalic neuronal and stimulate microglial cells prior to reactive oxygen species (ROS) measurement, immunohistochemistry and imaging studies.

生化/生理作用

α-Synuclein (α-Syn) interacts with toll-like receptor 2 (TLR2) and mediates interleukin-1β (IL-1β) synthesis.
A point mutation in the α-synuclein gene, A53T (Ala⁵³-Thr), is linked to familial Parkinson′s disease. Mice expressing A53T human α-synuclein, but not wild-type or the A30P variants, develop adult-onset neurodegenerative disease with aprogressive motoric dysfunction leading to death.

基本信息

MDL编号	MFCD06411759
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	200
重组	expressed inE. coli
测定	≥90% (SDS-PAGE)
形式	lyophilized powder
UniProt登记号	P37840
运输	dry ice
储存温度	?20℃
Gene Information	human ... SNCA(6622)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)