半岛bd体育手机客户端 说明
生化/生理作用
Synucleins (α, β, γ-synoretin) are a family of small, highly conserved proteins expressed primarily in neurons and certain tumors. β-Synuclein is an acidic, neuronal protein considered to be a non-amyloidogenic homolog of α-synuclein. It has been postulated that β-synuclein could act as a physiological inhibitor of α-synuclein aggregation and that it might protect the central nervous system from the neurotoxic effects of α-synuclein. The mechanisms of β-synuclein neuroprotection may involve direct interaction between β-synuclein and Akt, and thus suggest that this signaling pathway could be a therapeutic target for neurological conditions associated with Parkinson and α-synuclein aggregation. Overexpression of β-synuclein mutants (P123H and V70M) in neuroblastoma cells results in enhanced lysosomal pathology suggesting a causative role for these missensemutations in neurodegeneration stimulation.
外形
Lyophilized from a 0.2 μm filtered solution.
重悬
Reconstitute with 0.5 mL water (~1 mg/mL). Store in working aliquots at ?20 ℃.
基本信息
| MDL编号 | MFCD08705537 |
| NACRES | NA.32 |
半岛bd体育手机客户端 性质
| 质量水平 | 200 |
| 重组 | expressed inE. coli |
| 测定 | ≥90% (SDS-PAGE) |
| 形式 | lyophilized powder |
| UniProt登记号 | Q16143 |
| 运输 | dry ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... SNCB(6620) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
