半岛bd体育手机客户端 说明
一般描述
Amyloid-β (Aβ) peptides are a major component of the senile plaques characteristic of the Alzheimer brain. It is a type- I transmembrane protein. The gene encoding amyloid-β is localized on human chromosome 21.
应用
Human amyloid precursor protein β has been used as peptide standard.
包装
25 μg in glass bottle
生化/生理作用
The secreted amyloid precursor β (sAPPβ) is a proteolytic cleavage product of β amyloid precursor protein (APP). APP is cleaved by β-secretase into two fragments, sAPPβ and β-amyloid peptide (Aβ). The Aβ is a component of amyloid plaques, one of the major hallmarks of Alzheimer`s disease (AD), while the sAPPβ is thought to modulate neuronal function and cell survival. Mutation in APP found in Swedish familial AD pedigree increases the susceptibility of APP to β-secretase cleavage and the formation of Aβ and sAPPβ. In contrast, activation of protein kinase C (PKC) decreases the levels of sAPPβ. Thetrans-Golgi network (TGN) is the major site for β-secretase activity.
外形
0.2 μm filtered solution in 20 mM Tris (pH 7.4), 0.5 M NaCl, 1 mM EDTA, 5 mM βME, 2 μg/ml aprotinin
制备说明
sAPPβ was expressed inE. colias a soluble protein and purified under non-denaturing conditions
基本信息
| MDL编号 | MFCD06201921 |
| NACRES | NA.32 |
半岛bd体育手机客户端 性质
| 质量水平 | 200 |
| 重组 | expressed inE. coli(N-terminal histidine tagged) |
| 形式 | solution |
| 分子量 | ~100 kDa by SDS-PAGE |
| UniProt登记号 | P05067 |
| 运输 | dry ice |
| 储存温度 | ?70℃ |
| Gene Information | human ... APP(351) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich
m.cnreagent.com
