SUMO-1 human

半岛bd体育手机客户端 说明

一般描述

Small ubiquitin-like modifier 1 (SUMO-1), a protein, is one of the 5 SUMO paralogs expressed in mammalian cells with a low but significant homology with ubiquitin. This SUMO-1-GST fusion protein is produced from a DNA sequence corresponding to human SUMO-1 fused to a glutathione S-transferase (GST)-tag and is expressed in E. coli cells.

应用

SUMO-1 human has been used in pre-absorption for negative immunostaining to confirm the specificity of the small ubiquitin like modifier 1 (SUMO-1) antibody.

生化/生理作用

Small ubiquitin-like modifier 1 (SUMO-1) plays a key role in modulating survival, migration, and signal transduction in some cell lines. It can preventin vitromigration and invasion of RA fibroblast-like synoviocytes (FLSs). Higher expression of SUMO-1 may result in joint destruction in rheumatoid arthritis (RA).
Conjugated to a variety of proteins by UbcH9, including RanGAP1, IκBα, and PML without the requirement of an equivalent E3 ubiquitin ligase.

外形

Solution in 50 mM HEPES, pH 8.0, 150 mM NaCl and 1 mM DTT.

基本信息

MDL编号	MFCD03458656
NACRES	NA.32

半岛bd体育手机客户端 性质

重组	expressed inE. coli(GST-tagged)
质量水平	200
测定	≥95% (SDS-PAGE)
分子量	38.5 kDa
UniProt登记号	P63165
运输	dry ice
储存温度	?70℃
Gene Information	human ... SUMO1(7341)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)