STX64

半岛bd体育手机客户端 说明

生化/生理作用

STX64 is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC₅₀= 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C14H15NO5S
分子量	309.34
MDL编号	MFCD12912443
PubChem化学物质编号	329824496
NACRES	NA.77

半岛bd体育手机客户端 性质

测定	≥98% (HPLC)
形式	powder
颜色	white
溶解性	DMSO: >20 mg/mL
储存温度	2-8℃
SMILES string	NS(=O)(=O)Oc1ccc2C3=C(CCCCC3)C(=O)Oc2c1
InChI	1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18)
InChI key	DSLPMJSGSBLWRE-UHFFFAOYSA-N
Gene Information	human ... STS(412)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)