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一般描述

Sphingomyelinase (SMase) is a hydrolase, of 34.2 kDa and its active site contain as a minimum of two magnesium atoms.

应用

Sphingomyelinase has been used in a study to assess the interaction of actin with the HIV-1 accessory protein Nef. Sphingomyelinase has also been used in a study to investigate X-ray scattering as a quality-control tool for liposomal drug-delivery systems.
Sphingomyelinase fromBacillus cereushas been used:

• in the study to analyse the effect of sphingomyelinase on Rubella virus infectivity in cell lines
• in lipoprotein modification for the generation of cholesterol crystalsin vitro
• to aggregate LDL (low-density lipoprotein)

生化/生理作用

启动形成基于鞘磷脂的第二信使。激活 MAPK(丝裂原活化蛋白激酶)和 SAPKs(压力激活蛋白激酶)；从鞘磷脂生成神经酰胺。
Sphingomyelin phosphodiesterase (SMPD) participates in the metabolic reactions comprising sphingomyelin. SMPD has the ability to prevent colorectal carcinoma and colitis.

单位定义

One unit will hydrolyze 1.0 μmole of TNPAL-sphingomyelin per min at pH 7.4 at 37 ℃.

外形

Solution in 50% glycerol containing 50 mM Tris-HCl, pH 7.5.

基本信息

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安全信息