SCH-28080

半岛bd体育手机客户端 说明

应用

SCH-28080 was used to treat zebrafish embryos to study the role of H⁺/K⁺-ATPase in establishment of left-right axis during development.

包装

10, 50 mg in glass bottle

生化/生理作用

SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC₅₀s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC₅₀of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.

基本信息

经验(实验)分子式	C17H15N3O
分子量	277.32
MDL编号	MFCD00834620
PubChem化学物质编号	24278810
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
颜色	white to light tan
溶解性	DMSO: soluble >10 mg/mL H2O: insoluble
相容性	for use with ABI 7700
储存温度	?20℃
SMILES string	Cc1nc2c(OCc3ccccc3)cccn2c1CC#N
InChI	1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3
InChI key	PYKJFEPAUKAXNN-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)