半岛bd体育手机客户端 说明

一般描述

Stromal cell-derived factor-1 (SDF-1) is a proinflammatory cytokine that belongs to the CXC family of chemokines. The effects of SDF-1 are mediated by its binding to the receptor CXCR4, and sometimes to CXCR7. Both lymphoid (bone marrow, spleen and thymus) and non-lymphoid (stomach, kidney, liver, lung, brain, heart) organs express SDF-1. The most important functions assigned to SDF-1 are angiogenesis, migration of μglia and astrocytes, tissue repair and as chemoattractant to hematopoietic cells. Studies also implicate SDF-1 in survival of human glioma cells via the activation of PI3K/Akt pathway. The other pathways that are activated by SDF-1 include MAPK, NF-κB, paxillin, Crk and other focal adhesion proteins. A variety of human malignancies of pancreas, breast, prostate and glioma exhibit overexpression of CXCR4. High expression of SDF-1 has been observed in lymph nodes, lungs, bone and liver that are the most common sites of metastasis of breast cancer cells
This antibody can be used for the localization and detection of human SDF-1/PBSF. It can detect human SDF-1α and SDF-1β.

特异性

The antibody may be used for neutralization of SDF-1α and SDF-1β, and for localization and detection of human SDF-1/PBSF.

免疫原

recombinant human SDF-1/PBSF expressed inE. coli.

应用

Anti-SDF-1/PBSF antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For ELISA, the recommended working antibody concentration is 0.5-1.0 μg/ml. The antibody is also suitable for neutralization assays.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose..

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号

MFCD01864754

半岛bd体育手机客户端 性质

质量水平	100
生物来源	goat
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	lyophilized powder
species reactivity	human
technique(s)	indirect ELISA: 0.5-1 μg/mL neutralization: suitable western blot: 0.1-0.2 μg/mL
UniProt登记号	P48061
储存温度	?20℃
Gene Information	human ... CXCL12(6387)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable