半岛bd体育手机客户端 说明

一般描述

CHUK (conserved helix-loop-helix ubiquitous kinase) is located on human chromosome 10q24. IKK1/IKK-α has three ordered protein domains, namely, a kinase domain (KD), a ubiquitin-like domain (ULD) and a scaffold dimerization domain (SDD). IKKB (inhibitor of nuclear factor κ B kinase subunit β) is mapped to human chromosome 8p11. IKBKB codes for IκB kinase 2 (IKK2/IKKβ). IKK1 and IKK2 has a canonical MAP kinase kinase (MAPKK) activation loop motif.

免疫原

The antiserum was produced against synthesized peptide derived from human IKK-alpha around the phosphorylation site of Ser177.

Immunogen Range:151-200

生化/生理作用

IKK1/IKKα (I-κ-B kinase 1) modulates nuclear factor κ-B (NF-κB) signaling, that is required for lymphoid organogenesis and adaptive immunity. IκB kinase α (IKKα) plays a major role in human skin cancer. This gene also controls terminal differentiation and multiplication of keratinocytes. IKKβ acts as the master regulator of cell survival and the inflammatory response.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen 84 kDa
species reactivity	rat, mouse, human
浓度	~1 mg/mL
technique(s)	ELISA: 1:1000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000
NCBI登记号	O14920 O15111
UniProt登记号	O15111
运输	wet ice
储存温度	?20℃
Gene Information	human ... CHUK(1147), IKBKB(3551)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable