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Anti-Tau Antibody, clone Tau 7

品牌
Sigma-Aldrich
货号
MAB2239
规格纯度
clone Tau 7, from mouse
价格
6358.33 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Tau Antibody, clone Tau 7
G protein beta1/gamma2 subunit-interacting factor, Neurofibrillary tangle protein, Paired helical filament-tau, microtubule-associated protein tau, microtubule-associated protein tau, isoform 4
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Microtubule Associated Proteins, or MAPS, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I, II. Type II MAP includes MAP2, MAP4, and tau and are found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains.

特异性

Reactivity with other species has not been determined.
Cat. # MAB2239 recognizes the C-terminus region of Tau.

应用

This Anti-Tau Antibody, clone Tau 7 is validated for use in WB for the detection of Tau.

质量

Western Blot:

目标描述

50-68 kDa

外形

Protein G Purified
Format: Purified

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified antibody
antibody product type primary antibodies
克隆 Tau 7, monoclonal
species reactivity rat, human
technique(s) western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_001116538.1
UniProt登记号 P10636
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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