Anti-MAPT (Ab-214) antibody produced in rabbit

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一般描述

MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3. It is upregulated in neurons but is most prominent in axons.

免疫原

Peptide sequence around aa. 212-216 (T-P-S-L-P), according to the protein MAPT.

生化/生理作用

Removal of MAPT results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure.

特点和优势

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目标描述

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

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基本信息

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