半岛bd体育手机客户端 说明
一般描述
Mechanistic target of rapamycin kinase (MTOR) is a serine/threonine kinase. mTOR belongs to the family of phosphatidylinositol kinase-related kinase (PIKK). mTOR exists as two different complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). In human chromosome, the gene MTOR is localized on 1p36.22.
特异性
The antibody detects endogenous level of mTOR only when phosphorylated at Serine 2481.
免疫原
Peptide sequence around phosphorylation site of Serine 2481(I-H-S(p)-F-I) derived from Human mTOR.
应用
Anti-phospho-mTOR (pSer2481) antibody produced in rabbit has been used in western blot analysis.
生化/生理作用
Mechanistic target of rapamycin kinase (MTOR) recognizes various intracellular and extracellular signals and processes them to regulate cell growth, metabolism, proliferation and survival. mTOR is also involved in mitochondrial respiration by activating oxidative phosphorylation. Deregulation of mTOR phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) complex signalling pathway, leads to leukaemogenesis. Mutations leading to aberrant expression of mTOR causes cancer cachexia. mTOR plays a key role in synaptic plasticity and autophagy. Polymorphism of mTOR is associated with brain malformation and various neuropsychiatric disorders like brain ischemia, autism, epilepsy, schizophrenia etc. mTOR is a key regulator of anabolic and catabolic processes. mTOR is activated by insulin or insulin like growth factor 1 (IGF1) and regulate PI3K/Akt/mTOR/tuberous sclerosis (TSC)/the small GTPase (guanidine triphosphatase) Ras (rat sarcoma) homologue enriched in brain (RHEB) signalling pathway. mTOR is a key regulator of lipid biogenesis by influencing lipogenic genes like sterol regulatory element-binding protein 1 (SREBP1). Dysregulation of mTOR is associated with type 2 diabetes and obesity.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 288 kDa |
| species reactivity | human, rat, mouse |
| 浓度 | 1.0 mg/mL |
| technique(s) | western blot: 1:500-1:1000 (Cell Lysate) |
| 同位素/亚型 | IgG |
| 登记号 | NP_004949.1 |
| UniProt登记号 | P42345 |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... MTOR(2475) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
