Anti-phospho CARM1 (Ser228) Antibody

半岛bd体育手机客户端 说明

一般描述

CARM1 (coactivator-associated arginine methyltransferase 1) is an arginine N-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to arginine residues. This protein-arginine methyltransferase that works in conjunction with p300 and GRIP1 to enhance transcription. CARM1 methylation targets include histone H3 at Arg17 and p300 at Arg2142. CARM1 is recruited to promoters upon gene activation together with histone acetyltransferases from the p300 and p160 families. During monocyte inflammatory stimulation, CARM1 acts together with p300 as a coactivator for NF-kB. It is responsible for moving cells toward the inner cell mass in developing blastocysts. CARM1 also plays an important role in androgen receptors and may play a role in prostate cancer progression.

特异性

This antibody recognizes CARM1 phosphorylated at Ser228.

免疫原

KLH-conjugated linear peptide corresponding to human CARM1 phosphorylated at Ser228.
Epitope: Phosphorylated Ser228

应用

Research Sub Category
Chromatin Biology

Histones
Anti-phospho CARM1 (Ser228) Antibody is a Rabbit Polyclonal Antibody for detection of phospho CARM1 (Ser228) also known as Protein arginine N-methyltransferase 4 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function

质量

Evaluated by Western Blot in EGF treated and untreated A431 cell lysates.

Western Blot Analysis: 2 ?g/mL of this antibody detected CARM1 on 10 ?g of EGF treated and untreated A431 cell lysates.

目标描述

~63 kDa observed

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
EGF treated and untreated A431 cell lysates

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	horse, human
species reactivity (predicted by homology)	rat (based on 100% sequence homology), mouse (based on 100% sequence homology), canine (based on 100% sequence homology), bovine (based on 100% sequence homology), equine (based on 100% sequence homology)
technique(s)	western blot: suitable
NCBI登记号	NP_954592
UniProt登记号	Q86X55
运输	wet ice
Gene Information	human ... CARM1(10498)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable