半岛bd体育手机客户端 说明
一般描述
Ribosomal protein S6 kinase α-1 (RPS6KA1) or RSK1 is a member of the RSK (ribosomal S6 kinase) family that consists of growth factor-regulated serine/threonine kinases. RSK1 contains 2 nonidentical kinase catalytic domains. RSK1 encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. RSK1 transcript is present in lymphocytes, skeletal muscle, liver, and adipose tissue.
生化/生理作用
Ribosomal S6 kinases (RSKs) are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation. The protein suppresses the pro-apoptotic function of BAD by phosphorylating it. RSK1 phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
基本信息
NACRES | NA.32 |
半岛bd体育手机客户端 性质
质量水平 | 200 |
重组 | expressed in baculovirus infectedSf9 cells |
半岛bd体育手机客户端 线 | PRECISIO?Kinase |
测定 | ≥70% (SDS-PAGE) |
形式 | buffered aqueous glycerol solution |
specific activity | 159-215 nmol/min·mg |
分子量 | ~108 kDa |
UniProt登记号 | Q15418 |
运输 | dry ice |
储存温度 | ?70℃ |
Gene Information | human ... RPS6KA1(6195) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich