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Anti-Rab4 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
R5780
规格纯度
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
4915.81 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-Rab4 antibody produced in rabbit
Anti-HRES-1/RAB4
Anti-RAB4A
Anti-RAS-associated protein RAB4
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

There are two highly homologous RAB4 isoforms, RAB4A and RAB4B, encoded by two separate genes (RAB4A and RAB4B). RAB4A and RAB4B are localized in the same cellular compartments and are believed to have similar or identical functions in recycling.
Rab4 is a GTPase , that is located in early and recycling endosomes. It belongs to Rab family and is located on human chromosome 1q42. In rat testis, Rab4 is found in sertoli and germ cells.

应用

The antibody can be used in several immunochemical techniques including immunoblotting (24 kDa) and immunofluorescence.

生化/生理作用

Rab4 regulates endocytic recycling in a cell cycle dependent fashion. Rab4 is associated with early endosomes and recycling endosomes and regulates the recycling of membranes and proteins from these compartments back to the plasma membrane. Rab4 interacts with several Rab4 effector proteins like Rabip4, that regulates integrin trafficking and is involved in the migration of NIH 3T3 fibroblasts.
Rab4a controls integrin trafficking throughout cell adhesion. It helps in the quick reprocess of receptors from early endosomes to the cell surface. It also controls the secretion of procathepsin L in human melanoma cells.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD01634072
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~24 kDa
species reactivity human, rat, mouse
浓度 ~1.0 mg/mL
technique(s) indirect immunofluorescence: 5-10 μg/mL using mouse 3T3 and rat NRK cells fixed and permeabilized with 4% paraformaldehyde followed by 0.1% and 0.4% saponin, respectively.
western blot: 2-5 μg/mL using whole extract of human HEK-293T cells
UniProt登记号 P20338
运输 dry ice
储存温度 ?20℃
Gene Information human ... RAB4A(5867)
mouse ... Rab4a(19341)
rat ... Rab4a(25532)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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