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Anti-RACK1 (N-terminal) antibody produced in rabbit

Anti-RACK1 (N-terminal) 兔抗

品牌
Sigma-Aldrich
货号
R1905
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
5045.46 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-RACK1 (N-terminal) antibody produced in rabbit
Anti-Proliferation-inducing gene 21
Anti-Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Anti-protein homologous to chicken B complex protein
Anti-HLC-7
Anti-PIG21
Anti-GNB2L1
Anti-H12.3
Anti-Lung cancer oncogene 7
Anti-Gnb2-rs1
Anti-Receptor of Activated Protein Kinase C1
Anti-RACK1 (N-terminal) 兔抗
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Receptors for activated C-kinase (RACKs) are scaffold protein for Protein kinase C (PKC). It is composed of seven WD (Trp-Asp) repeats, thus resembling the structure of the subunit of G proteins.

特异性

Anti-RACK1 (N-terminal) is produced in rabbit and specifically recognizes human RACK1. Anti-RACK1 (N-terminal) antibody is specific for human RACK1 (approx. 30 kDa). The antibody also reacts with rat and mouse RACK1. In immunoblotting, staining of the RACK1 band is specifically inhibited by the immunizing peptide.

免疫原

synthetic peptide corresponding to amino acids 2-16 of human RACK1, conjugated to KLH via an C-terminal added cysteine residue. The corresponding sequence is conserved in human, rat and mouse.

应用

Anti-RACK1 (N-terminal) antibody is suitable for use in indirect immunofluorescence (1:100-1:200 using paraformaldehyde-fixed HeLa cells), western blot (1:500-1:1,000 using HEK-293T cell lysates) and immunoprecipitation (5-10 μL using HEK-293T cell lysates).
It is also used in immunoblotting.

生化/生理作用

RACK1 is a receptor for activated C kinases that functions downstream of the growth factor receptor signaling pathway. RACK1 also modulates several functions such as cell adhesion, chemotaxis and protrusion. Increased RACK1 expression has been associated with cell migration and metastasis in breast carcinoma. Thus, RACK1 can be used as a prognostic indicator for breast cancer
Receptors for activated C-kinase (RACKs) anchor activated Protein kinase C (PKC) at the site of translocation. Receptors for activated C-kinase 1 (RACK1) is the selective RACK for PKC-βII. RACK1 anchors other signaling enzymes such as Sarcoma (Src) tyrosine kinase, integrin and phosphodiesterase 4D5. The ability of RACK1 to interact simultaneously with different signaling molecules, allows it to integrate inputs from distinct signaling pathways. Accumulating evidence attributes to it the role of regulating several major nervous system pathways. RACK1 is a ribosomal protein and can make direct contact with ribosomal RNA. It recruits activated PKC to the ribosome, which in turn, phosphorylates initiation factor 6, leading to ribosome assembly.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD01634078
NACRES NA.44

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 IgG fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~30 kDa
species reactivity mouse, human, rat
technique(s) immunoprecipitation (IP): 5-10 μL using HEK-293T cell lysates
indirect immunofluorescence: 1:100-1:200 using paraformaldehyde-fixed HeLa cells
western blot: 1:500-1:1,000 using HEK-293T cell lystes
运输 dry ice
储存温度 ?20℃
Gene Information human ... GNB2L1(10399)
mouse ... Gnb2l1(14694)
rat ... Gnb2l1(83427)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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