PKA Inhibitor 5-24-CAS 99534-03-9-Calbiochem

品牌

Sigma-Aldrich

CAS

99534-03-9

货号

116805

包装型号

500 μG, The PKA Inhibitor 5-24, also referenced under CAS 99534-03-9, controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appli

规格纯度

The PKA Inhibitor 5-24, also referenced under CAS 99534-03-9, controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

价格

3124.36 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

99534-03-9
PKA Inhibitor 5-24-CAS 99534-03-9-Calbiochem
Protein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A potent synthetic peptide that is a competitive inhibitor of protein kinase A (K_i= 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. Binds to the catalytic subunit of PKA and displaces the regulatory subunit. Mimics the protein substrate by binding to the catalytic site via the arginine-cluster basic substrate.
Peptide corresponding to the active site on the skeletal muscle inhibitor protein. Competitive inhibitor of protein kinase A (K_i= 2.3 nM).

包装

500 μg in Plastic ampoule
Yes

生化/生理作用

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Target K_i: 2.3 nM for protein kinase A

警告

Toxicity: Standard Handling (A)

序列

H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH

制备说明

Sonication or the addition of a few drops of dilute acid (10 mM HCl) may be necessary to achieve complete solubilization.

其他说明

Knighton, D.R., et al. 1991.Science253,525.
Cheng, H.C., et al. 1986.J. Biol. Chem.261,989.
Rusine, T., et al. 1986.J. Cell Biol.102,1630.
Wong, Y.S., et al. 1986.J. Biol. Chem..261,12089.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₉₄H₁₄₈N₃₂O₃₁
分子量	2222.38
MDL编号	MFCD00133989

半岛bd体育手机客户端性质

质量水平	100
测定	≥95% (HPLC)
形式	lyophilized
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze desiccated (hygroscopic)
溶解性	water: 1 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C94H148N32O31/c1-11-42(3)70(124-85(150)58(31-50-19-14-13-15-20-50)117-84(149)61(35-67(135)136)116-74(139)44(5)110-81(146)57(32-51-24-26-53(131)27-25-51)119-90(155)73(49(10)130)126-86(151)69(96)47(8)128)88(153)112-45(6)75(140)122-63(40-127)77(142)107-38-65(133)114-55(22-17-29-105-93(99)100)80(145)125-72(48(9)129)87(152)108-39-66(134)113-54(21-16-28-104-92(97)98)78(143)115-56(23-18-30-106-94(101)102)79(144)118-60(34-64(95)132)82(147)111-46(7)76(141)123-71(43(4)12-2)89(154)120-59(33-52-37-103-41-109-52)83(148)121-62(91(156)157)36-68(137)138/h13-15,19-20,24-27,37,41-49,54-63,69-73,127-131H,11-12,16-18,21-23,28-36,38-40,96H2,1-10H3,(H2,95,132)(H,103,109)(H,107,142)(H,108,152)(H,110,146)(H,111,147)(H,112,153)(H,113,134)(H,114,133)(H,115,143)(H,116,139)(H,117,149)(H,118,144)(H,119,155)(H,120,154)(H,121,148)(H,122,140)(H,123,141)(H,124,150)(H,125,145)(H,126,151)(H,135,136)(H,137,138)(H,156,157)(H4,97,98,104)(H4,99,100,105)(H4,101,102,106)/t42-,43-,44-,45-,46-,47?,48?,49?,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,69-,70-,71-,72-,73-/m0/s1
InChI key	AXOXZJJMUVSZQY-BVDKBYOBSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable