PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated-Calbiochem

半岛bd体育手机客户端 说明

一般描述

Heat-stable protein kinase inhibitor (PKI) peptide sequence (14 - 22) that has been myristoylated at the N-terminus, enhancing its cell-permeability. The non-myristoylated version of this peptide is a highly specific inhibitor (K_i= 36 nM) of cAMP-dependent protein kinase.
Heat-stable protein kinase inhibitor (PKI) peptide sequence (14-22) that has been myristoylated at the N-terminus, enhancing its cell-permeability. The non-myristoylated version of this peptide is a highly specific inhibitor (K_i= 36 nM) of cAMP-dependent protein kinase (PKA).

包装

500 μg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Cell permeable: yes
Primary Target
cAMP-dependent protein kinase
Target K_i: 36 nMf or cAMP-dependent protein kinase
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH?

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Paman, K., et al. 1998.J. Lipid Res.39,1091.
Rimon, G., and Rubin M. 1998.Biochim. Biophys. Acta1380,289.
Harris, T.E., et al. 1997.Biochem. Biophys. Res. Commun.232,648.
Muniz, M., et al. 1997.Proc. Natl. Acad. Sci. USA94,14461.
Zoukhri, D., et al. 1997.Am. J. Physiol.272,C263.
Eichholtz, T., et al. 1993.J. Biol. Chem.268,1982.
Ward, N.E. and O’Brian, C.A. 1993.Biochemistry32,11903.
Walsh, D.A. and Glass, D.B. 1991.Methods Enzymol.201,304.
Glass, D.B., et al. 1989.J. Biol. Chem.264,8802.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

半岛bd体育手机客户端 性质

安全信息